反应详情

A solution of 1.65 g of 5-(p-cyanophenyl)-3-ethoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine in 10 ml of methanol containing 0.2 g of sodium hydroxide is stirred for 3 h at room temperature. The solution is warmed to reflux and 5 ml of 1N hydrochloric acid is added. After 1 h the reaction mixture is cooled and evaporated. The residue is partitioned between water and ethyl acetate. The organic layer is separated, dried over sodium sulfate and evaporated to yield 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine, m.p. 128°-131°.

1. temperatureThe solution is warmed
2. temperatureto reflux
3. temperatureAfter 1 h the reaction mixture is cooled
4. customevaporated
5. customThe residue is partitioned between water and ethyl acetate
6. customThe organic layer is separated
7. dry with materialdried over sodium sulfate
8. customevaporated