反应详情

The title compound was prepared from 1-Boc-4-hydroxypiperidine and 4-chloro-3-methylpyridine hydrochloride, using a similar method to preparation 27. The reaction mixture was stirred for 72 hours to afford the title compound the desired product in 87% yield. 1H NMR(CDCl3, 400 MHz) δ: 1.44(s, 9H), 1.75-1.85(m, 2H), 1.87-1.97(m, 2H), 2.18(s, 3H), 3.42-3.53(m, 2H), 3.56-3.65(m, 2H), 4.57-4.65(m, 1H), 6.72(d, 1H), 8.29(s, 1H), 8.35(d, 1H); LRMS APCI m/z 293 [M+H]+

1. customto preparation 27