反应详情

A solution of (6-{4-[2-(2,6-dichloro-phenyl)-4-isopropyl-2H-pyrazol-3-ylmethoxy]-2-methyl-phenyl}-benzo[b]thiophen-3-yl)-acetic acid ethyl ester (43 mg; 0.072 mmoles) in tetrahydrofuran (1.0 mL) and methanol (1.0 mL) is treated with sodium hydroxide (1.0 mL; 1.0 N). The mixture is stirred at room temperature for 2 hours and quenched with HCl (1.0 mL, 1.0 M). The mixture is extracted with EtOAc (10 mL×2). The combined organic layers are dried over Na2SO4, filtered and concentrated. The crude product is purified by flash chromatography (eluting with 30-100% EtOAc/Hexanes) and the appropriate fractions are concentrated. The material is dried in vacuo to afford the title compound (28 mg, 68%). ES/MS m/e 564.8; 566.8 (M+1); 562.8; 564.8 (M−1)

1. customquenched with HCl (1.0 mL, 1.0 M)
2. extractionThe mixture is extracted with EtOAc (10 mL×2)
3. dry with materialThe combined organic layers are dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe crude product is purified by flash chromatography (eluting with 30-100% EtOAc/Hexanes)
7. concentrationthe appropriate fractions are concentrated
8. customThe material is dried in vacuo