反应详情

The title compound was prepared in an analogous fashion to 1-cyclopropyl-3-(2-fluoro-4-iodo-phenylamino)-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (2,3-dihydroxy-propoxy)-amide, replacing O-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-hydroxylamine with O—((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-hydroxylamine. 1H-NMR (500 MHz, DMSO-d6) δ ppm 11.60 (s, 1H), 8.53 (s, 1H), 8.32 (d, J=5.86 Hz, 1H), 7.57 (d, J=5.69 Hz, 1H), 7.53-7.48 (m, 2H), 7.20 (d, J=8.06 Hz, 1H), 6.26 (t, J=8.81 Hz, 1H), 4.87 (d, J=4.05 Hz, 1H), 4.60 (t, J=5.43 Hz, 1H), 3.94 (dd, J=9.88, 2.80 Hz, 1H), 3.76 (t, J=8.0 Hz, 1H), 3.70 (broad s, 1H), 3.56-3.45 (m, 1H), 3.40-3.34 (m, 2H), 1.15-1.08 (m, 2H), 0.88-0.83 (m, 2H); LC-MS (method E): [M+H]+=527.1, RT=7.31 min.