反应详情

A solution of [3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-yloxy]acetic acid methyl ester (0.045 g), acetonitrile (2.0 mL), tetrahydrofuran (1.0 mL) and 4.0 M aqueous lithium hydroxide solution (2.0 mL) was stirred at room temperature for 2 hours. The organic solvents were removed under reduced pressure and the pH of the residue adjusted to 5-6 by the addition of saturated aqueous sodium dihydrogenphosphate solution. The resulting mixture was extracted with chloroform and the combined extracts dried over magnesium sulfate. The solvent was removed under reduced pressure and trituration of the residue with diethyl ether and then methanol gave title compound, 0.025 g.

1. customThe organic solvents were removed under reduced pressure
2. additionthe pH of the residue adjusted to 5-6 by the addition of saturated aqueous sodium dihydrogenphosphate solution
3. extractionThe resulting mixture was extracted with chloroform
4. dry with materialthe combined extracts dried over magnesium sulfate
5. customThe solvent was removed under reduced pressure and trituration of the residue with diethyl ether