反应详情

The title compound was prepared by a similar method to example 38 using 2-{2-[(1-benzhydryl-3-azetidinyl)amino]ethyl}-9-[(2R,3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethyl)tetrahydro-2-furanyl]-N-(2,2-diphenylethyl)-9H-purin-6-amine (130 mg, 0.14 mmol) (preparation 38) and a 1 molar solution of tetra-n-butylammonium fluoride in tetrahydrofuran (0.4 ml, 0.4 mmol). The compound was purified by column chromatography on silica gel eluting with a solvent gradient of dichloromethane:methanol:ammonia (95:5:0.5) increasing in polarity to (90:10:1) to give the title compound (70 mg) as a foam. MS: 726 (MH+).

1. customThe compound was purified by column chromatography on silica gel eluting with a solvent gradient of dichloromethane:methanol:ammonia (95:5:0.5)
2. temperatureincreasing in polarity to (90:10:1)