Diethyl Ether → HCID 11562468, Verbindung

HRID 2268853Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2268853
[Br:1][CH:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][CH3:12])=[CH:8][CH:9]=2)[C:4](=[O:13])[O:3]1.[C:14]1([P:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(OCC)C>C(#N)C>[Br-:1].[CH3:12][O:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:2]([P+:20]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[O:3][C:4]2=[O:13]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 11776TriphenylphosphineHCID 122985403-bromo-6-methoxyisobenzofuran-1(3H)-one

Produkt 1

HCID 11562468HCID 11562468, VerbindungAusbeute 91,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

3-Bromo-6-methoxy-3H-isobenzofuran-1-one (41 g, 0.169 mole), prepared as described in example 35, suspended in dry acetonitrile (205 ml) under N2 was added with triphenylphosphine (42 g, 0.16 mole). The mixture was refluxed and after about 3 hours cooled and concentrated to give a solid, which was treated with ethyl ether, filtered and brought to dryness under vacuum. There were thus obtained 74 g of the title compound (yield: 84%).

Aufarbeitung

  1. temperatureThe mixture was refluxed and after about 3 hours
  2. temperaturecooled
  3. concentrationconcentrated
  4. customto give a solid, which
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-bd3fc579e1ed4dd0a7d55843678ea4e1
Quelldatensatz
uspto-grants-2001_12
Patentnummer
US06329370B1

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