反应详情

Experimental conditions analogous to those described for Step 6 of Example 60 from 90 mg (0.22 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 0.98 mL 0.5M 3-fluoro-4-methoxyphenylmagnesium bromide. Yield: 57 mg of a white solid. 1H NMR (400 MHz, CDCl3): δ 4.0 (s, 3H), 5.5 (s, 2H), 6.9-7.0 (m, 2H), 7.3-7.4 (m, 1H), 7.4-7.6 (m, 3H), 7.6-7.7 (m, 3H), 8.3 (s, 1H), 8.4-8.5 (m, 1H). LC-MSD, m/z for C23H16BrFN2O3 [M+H]+=467.0, 469.0; HPLC retention time: 2.3 min.