反应详情

This compound was prepared, starting from compound 16 (251 mg, 0.49 mmol), according to the procedure developed for compound 11 to give compound 17 (231 mg, 0.40 mmol) as a very hygroscopic yellow solid. Yield 80%; mp 99-101° C. (dec.); IR (KBr) ν 1163, 1225, 1421, 1474, 1522, 1622, 1670, 2500-2800, 2850-3000, 3100-3600 cm−1; 1H NMR (400 MHz, DMSO-d6) δ 1.28 (t, 3H, J=7.0 Hz), 3.33 (q, 2H, J=6.6 Hz), 3.62 (m, 2H), 3.80 (m, 6H), 6.12 (dd, 1H, J=2.0, 8.0 Hz), 6.40 (dd, 1H, J=2.0, 8.0 Hz), 7.30 (se, 1H), 7.50 (q, 1H, 4JH-F=8.0 Hz, J=8.0 Hz), 7.92 (d, 1H, J=8.8 Hz), 8.25 (dd, 1H, J=1.8, 8.8 Hz), 8.64 (d, 1H, J=1.6 Hz), 9.38 (t, 1H, J=6.0 Hz), 9.44 (s, 1H), 10.28 (se, 1H); ESI-MS m/z 509.1 [M+H]+; Anal. Calcd for C20H22OIN6F, 2HCl: C, 41.33; H, 4.16; N, 14.46. Found: C, 43.19; H, 4.31; N, 14.74.

1. customThis compound was prepared