HRID2276082

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2155

2-Aminothiazole

C3H4N2S

HCID73895

Benzene, 1-fluoro-2-nitro-

C6H4FNO2

HCID123571

(2,3,4-Trimethoxyphenyl)methanol

C10H14O4

HCID66998842

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(COc2ccccc2NC(=O)Nc2nccs2)c(OC)c1OC

HCID59732707

未命名化合物

收率 65%

结构：COc1ccc(COc2ccccc2[N+](=O)[O-])c(OC)c1OC

HCID66998910

未命名化合物

收率 72%

PROCEDURE

实验过程

2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene (0.46 g, 72%) was prepared from 2,3,4-trimethoxybenzyl alcohol (0.35 ml, 2.0 mmol) and 1-fluoro-2-nitrobenzene (0.21 ml, 2.0 mmol) following the general procedure G. This was reduced to 2-(2,3,4-trimethoxybenzyl-oxy)aniline (0.26 g, 65%) following the general procedure B. N-[2-(2,3,4-trimethoxybenzyl-oxy)phenyl]-N′-(thiazol-2-yl)urea (240 mg, 65%) was prepared from 2-(2,3,4-trimethoxybenzyloxy)aniline (0.26 g, 0.9 mmol) and 2-aminothiazole (140 mg, 1.4 mmol) following the general procedure D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-16f9fc9348164d3eb35e44e23195c4b3
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: USRE045670E1
来源说明: uspto-grants-2015_09

反应 SMILES

[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5][OH:6].F[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N+:22]([O-:24])=[O:23].[CH3:25][O:26][C:27]1[C:41]([O:42][CH3:43])=[C:40]([O:44][CH3:45])[CH:39]=[CH:38][C:28]=1[CH2:29][O:30][C:31]1[CH:37]=[CH:36][CH:35]=[CH:34][C:32]=1[NH2:33].[NH2:46][C:47]1[S:48][CH:49]=[CH:50][N:51]=1>>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5][O:6][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N+:22]([O-:24])=[O:23].[CH3:25][O:26][C:27]1[C:41]([O:42][CH3:43])=[C:40]([O:44][CH3:45])[CH:39]=[CH:38][C:28]=1[CH2:29][O:30][C:31]1[CH:37]=[CH:36][CH:35]=[CH:34][C:32]=1[NH:33][C:14]([NH:46][C:47]1[S:48][CH:49]=[CH:50][N:51]=1)=[O:13]