反应详情

温度

80 °C

In a 25 mL sealed tube, was added 4-(3-(1-trityl-1H-pyrazol-4-yl)pyridin-2-yloxy)benzenamine (0.150 g, 0.303 mmol), trifluoroacetic acid (0.23 mL, 3.0 mmol), and methanol (1.0 mL). The mixture was stirred at 80° C. for 36 hours. The mixture was concentrated. The residue was extracted into EtOAc, washed 1×NaHCO3, 1×NaCl, and the organic layers were combined and dried over Mg2SO4, filtered through fritted funnel and concentrated to yield 4-(3-(1H-pyrazol-4-yl)pyridin-2-yloxy)benzenamine as dark brown waxy solid. MS m/z=253 [M+1]+. Calc'd for C14H12N4O: 252.27.

1. customIn a 25 mL sealed tube
2. concentrationThe mixture was concentrated
3. extractionThe residue was extracted into EtOAc
4. washwashed 1×NaHCO3, 1×NaCl
5. dry with materialdried over Mg2SO4
6. filtrationfiltered through fritted funnel
7. concentrationconcentrated