反应详情

温度

40 °C

19 mg of 2-ethyl-4-[6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 0.4 ml of THF and treated with 1.5 ml of hydrochloric acid (4M in dry dioxane). After stirring at rt overnight and at 40° C. for 2 h the volatiles were removed in vacuo. The residue was triturated with dioxane and the resulting solid was isolated by suction. 8 mg (57%) of the title compound were obtained.

1. customwere removed in vacuo
2. customThe residue was triturated with dioxane
3. customthe resulting solid was isolated by suction