HRID2279536

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68294638

未命名化合物

HCID71743546

未命名化合物

结构：CC(C)(C)OC(=O)NCC[C@@H](N)c1ccc(C(F)(F)F)c(F)c1

HCID86705529

未命名化合物

PRODUCTS

生成物

结构：CC(C)Nc1ncc2c(n1)CN(C(=O)N[C@H](CCNC(=O)OC(C)(C)C)c1ccc(C(F)(F)F)c(F)c1)CC2

HCID68294477

未命名化合物

收率 39%

PROCEDURE

实验过程

Condensation of 290 and 72 was carried out in accord with the procedure described in step 6 of example 1 except 290 was used in place of 28 and 72 was used in place of 22. The crude product was purified by SiO2 chromatography eluting with DCM/MeOH gradient (500:8 to 500:15) to afford 0.090 g (39.0%) of (R)-tert-butyl 3-(3-fluoro-4-(trifluoromethyl)phenyl)-3-(2-(isopropylamino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxamido)propylcarbamate (292).

WORKUP

后处理

customThe crude product was purified by SiO2 chromatography
washeluting with DCM/MeOH gradient (500:8 to 500:15)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-07a7a4ca353b4cd1b57309be3527d71e
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09133187B2
来源说明: uspto-grants-2015_09

反应 SMILES

[NH2:1][C@@H:2]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[C:15]([F:23])[CH:14]=1)[CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].O1C[CH2:28][CH:27]([NH:30][C:31]2[N:32]=[CH:33][C:34]3[CH2:40][CH2:39][NH:38][CH2:37][C:35]=3[N:36]=2)[CH2:26]C1.Cl.ClC1C=C(C(C2[O:56][CH:55]=NC=2)N)C=CC=1Cl>>[F:23][C:15]1[CH:14]=[C:13]([C@H:2]([NH:1][C:55]([N:38]2[CH2:39][CH2:40][C:34]3[CH:33]=[N:32][C:31]([NH:30][CH:27]([CH3:26])[CH3:28])=[N:36][C:35]=3[CH2:37]2)=[O:56])[CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:9])[CH3:10])[CH:18]=[CH:17][C:16]=1[C:19]([F:20])([F:21])[F:22]