HRID2279707
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
Prepared analogously to Compound 1A using diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate (Compound 2B). 1H NMR (400 MHz, DMSO-d6) δ 10.66 (br s, 1H), 9.74 (s, 1H), 8.46-9.05 (m, 2H), 8.41 (s, 1H), 8.00 (br s, 1H), 7.82 (s, 1H), 7.10-7.53 (m, 4H), 4.62 (s, 2H), 4.20 (t, J=6.4 Hz, 2H), 3.70 (quin, J=7 Hz, 2H), 3.45 (t, J=6.1 Hz, 2H), 3.11 (s, 3H), 2.84 (d, J=20.2 Hz, 2H), 1.96 (quin, J=6.3 Hz, 2H), 1.01 (t, J=6.7 Hz, 3H) [OH proton obscured]. HRMS (ESI): m/z 646.14 [M+H]+. UPLC: tR=1.16 min (UPLC-TOF: polar—3 min).
WORKUP
后处理
- customtR=1.16 min (UPLC-TOF: polar—3 min)