反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
This material was prepared analogously to Compound 3A using diethyl[4-({4-[(7-{1-[(2S)-2,3-dihydroxypropyl]-1H-pyrazol-4-yl}-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl) pyrimidin-2-yl}amino)-3-methoxybenzyl]phosphonate (Compound 5B, 254 mg, 353 μmol) to yield 184 mg of the desired product (75%). 1H NMR (400 MHz, CD3OD) δ 8.42 (br. s., 1H), 8.20 (br. s., 1H), 8.08-8.16 (m, 1H), 8.06 (br. s., 1H), 7.80 (s, 1H), 7.57 (d, J=8.6 Hz, 1H), 7.09 (br. s., 1H), 6.95 (d, J=7.8 Hz, 1H), 4.37 (dd, J=4.17, 14 Hz, 3H), 4.16-4.26 (m, 1H), 4.07 (dd, J=4.6, 7.3 Hz, 1H), 3.88-3.97 (m, 2H), 3.87 (s, 3H), 3.58 (d, J=5.3 Hz, 2H), 3.10 (br. s., 3H), 3.01-3.08 (m, 2H), 1.21 (t, J=7 Hz, 3H). MS (ESI): m/z 692.21 [M+H]+. UPLC: tR=1.10 min (UPLC-TOF: polar—3 min).