反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
Prepared analogously to Compound 1B using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 1 E, 251 mg, 0.553 mmol) and 3-amino-6-[1-(3-hydroxypropyl)-3-methoxy-1H-pyrazol-4-yl]-N-methylpyridine-2-carboxamide (Compound 48C, 177 mg, 0.580 mmol) to afford 139 mg of the title compound (35%). 1H NMR (400 MHz, CD3OD) δ 8.90 (br. s., 1H), 8.33 (s, 2H), 7.85 (d, J=8.1 Hz, 1H), 7.79 (d, J=8.6 Hz, 1H), 7.02-7.07 (m, 1H), 6.90 (td, J=2.4, 8.1 Hz, 1H), 4.15 (t, J=6.7 Hz, 2H), 4.00-4.10 (m, 7H), 3.90 (s, 3H), 3.59 (t, J=6.2 Hz, 2H), 3.26 (s, 2H), 2.98 (s, 3H), 2.08 (quin, J=6.5 Hz, 2H), 1.20-1.27 (m, 6H). MS (ESI): m/z=723.42 [M+H]+. UPLC: tR=1.31 min (UPLC-TOF: polar—2 min).