反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
Prepared analogously to Compound 1B using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 1 E, 236 mg, 0.520 mmol) and 3-amino-6-[3-cyano-1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-N-methylpyridine-2-carboxamide (Compound 52C, 164 mg, 0.546 mmol) to afford 259 mg of the title compound (69%). 1H NMR (400 MHz, CD3OD) δ 9.17 (br. s., 1H), 8.47 (s, 1H), 8.38 (s, 1H), 7.91 (d, J=9.1 Hz, 1H), 7.68 (br. s., 1H), 7.08 (s, 1H), 6.98 (d, J=7.8 Hz, 1H), 4.52 (t, J=6.9 Hz, 2H), 4.08 (quin, J=7.3 Hz, 4H), 3.88 (s, 2H), 3.61 (t, J=6.1 Hz, 2H), 3.33-3.42 (m, 2H), 2.99 (s, 3H), 2.17 (quin, J=6.5 Hz, 2H), 1.26 (t, J=7.1 Hz, 7H). MS (ESI): m/z=718.47 [M+H]+. UPLC: tR=1.39 min (UPLC-TOF: polar—2 min).