反应详情

Prepared analogously to Compound 44A using ethyl hydrogen (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 38C, 124 mg, 0.200 mmol) and (3-{[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}oxetan-3-yl)methanol (Compound 60B, 75 mg, 0.24 mmol) to give the desired product. MS (ESI): m/z 909.76/911.76 [M+H]+. UPLC: tR=1.63 min (analytical 2 min).