反应详情

Methyl 2-((S)-6-((2′,6′-dimethyl-4′-(((R)-tetrahydrofuran-3-yl)oxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetate 2d (201 mg, 0.41 mmol) was dissolved in 15 mL of methanol. The reaction solution was added with 2M aqueous sodium hydroxide solution (2 mL, 4.10 mmol) and stirred for 3 hours. The resulting solution was concentrated under reduced pressure, mixed with 10 mL of water, and 1M hydrochloric acid was added dropwise to adjust the pH to 2-3. The solution was extracted with ethyl acetate (20 mL×2). The combined organic extracts were washed with saturated sodium chloride solution (30 mL), dried with anhydrous magnesium sulphate, and filtered. The filtrate was concentrated under reduced pressure to obtain the title compound 2-((S)-6-((2′,6′-dimethyl-4′-(((R)-tetrahydrofuran-3-yl)oxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid 2 (150 mg, yield 77.1%) as a white solid.

1. concentrationThe resulting solution was concentrated under reduced pressure
2. additionmixed with 10 mL of water, and 1M hydrochloric acid
3. additionwas added dropwise
4. extractionThe solution was extracted with ethyl acetate (20 mL×2)
5. washThe combined organic extracts were washed with saturated sodium chloride solution (30 mL)
6. dry with materialdried with anhydrous magnesium sulphate
7. filtrationfiltered
8. concentrationThe filtrate was concentrated under reduced pressure