反应详情

6,7-Dimethoxy-4-(4-methyl-2-nitrophenoxy)quinoline (480 mg) was dissolved in triethylamine/N,N-dimethylformamide (2 ml/10 ml), and palladium hydroxide (1.2 g) was added to the solution. The mixture was stirred at room temperature in a hydrogen gas atmosphere overnight. The reaction solution was filtered through Celite, and the solvent was removed therefrom by distillation under the reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by column chromatography using acetone-chloroform to give 4-(2-amino-4-methylphenoxy)-6,7-dimethoxyquinoline (240 mg, yield 55%).

1. filtrationThe reaction solution was filtered through Celite
2. customthe solvent was removed
3. distillationby distillation under the reduced pressure
4. additionWater was added to the residue
5. extractionthe mixture was extracted with ethyl acetate
6. washThe ethyl acetate layer was then washed with water and saturated brine
7. dry with materialwas dried over anhydrous sodium sulfate
8. customThe solvent was removed
9. distillationby distillation under the reduced pressure
10. customthe residue was purified by column chromatography