反应详情

温度

180 °C

2-Hydroxy-5-methoxyacetophenone (3.00 g), 7-benzyloxy-4-chloro-6-methoxyquinoline (6.65 g), and 4-dimethylaminopyridine (4.90 g) were suspended in o-dichlorobenzene (30 ml), and the suspension was stirred at 180° C. for 2 hr. The reaction solution was cooled to room temperature, and the solvent was then removed by distillation under the reduced pressure. Water was added to the residue, and the mixture was extracted with chloroform. The chloroform layer was then washed with water and saturated brine and was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography using acetone-chloroform to give 1-[2-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-5-methoxy-phenyl]-ethanone (2.53 g, yield 59%).

1. temperatureThe reaction solution was cooled to room temperature
2. customthe solvent was then removed by distillation under the reduced pressure
3. additionWater was added to the residue
4. extractionthe mixture was extracted with chloroform
5. washThe chloroform layer was then washed with water and saturated brine
6. dry with materialwas dried over anhydrous magnesium sulfate
7. customThe solvent was removed by distillation under the reduced pressure
8. customthe residue was purified by column chromatography