反应详情

温度

0 °C

Trifluoroacetic acid (1 ml) was added to N-{2-[6-methoxy-4-(2-methyl-quinolin-3-yloxy)-quinolin-7-yloxy]-ethyl}-N′,N″-diboc-guanidine (222 mg) at 0° C., and the mixture was then stirred at 0° C. for 2 hr. The reaction solution was made alkaline by the addition of a 1 N aqueous sodium hydroxide solution and was extracted with n-butanol. The n-butanol layer was washed with water and was then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-methanol to give the title compound (150 mg, yield 100%).

1. extractionwas extracted with n-butanol
2. washThe n-butanol layer was washed with water
3. dry with materialwas then dried over anhydrous magnesium sulfate
4. customThe solvent was removed by distillation under the reduced pressure
5. customthe residue was purified by thin layer chromatography