反应详情

Zinc powder (0.759 g, 11.6 mmole) was suspended in THF (13 mL). TiCl4 (0.640 mL, 5.84 mmole) was added dropwise and the resulting mixture was heated to reflux for 60 min. A solution of (4-bromophenyl)(4-hydroxyphenyl)methanone (2) (0.404 g, 1.46 mmole) and tetrahydropyran-4-one (0.405 mL, 4.38 mmole) in THF (2 mL) was added. The resulting mixture was heated to reflux for 2 h, then was allowed to cool to RT. A 10% aqueous solution of K2CO3(25 mL) was added and the mixture was filtered through a pad of Celite. The filtrate was separated and the aqueous layer was extracted with EtOAc (2×20 mL). The organics were washed with water (25 mL) and brine (25 mL), then dried (MgSO4) and concentrated. The residue was purified by silica gel chromatography (Isco Sg100c, RediSep 12 g cartridge and a gradient consisting of 10% EtOAc:hexanes for 5 min, 10% to 30% EtOAc:hexanes over 15 min, then 30% EtOAc:hexanes for 5 min) to provide 0.31 g (62%) of compound 46 as a white solid. 1H NMR (CDCl3): δ 7.41 (d, J=8.3 Hz, 2H), 6.97 (d, J=8.6 Hz, 2H), 6.95 (d, J=8.6 Hz, 2H), 6.75 (d, J=8.3 Hz, 2H), 4.97 (s, 1H), 3.72 (dd, J=10.0, 5.0 Hz, 4H), 2.40 (t, J=5.0 Hz, 2H), 2.36 (t, J=5.0 Hz, 2H).

1. temperaturethe resulting mixture was heated
2. temperatureto reflux for 60 min
3. temperatureThe resulting mixture was heated
4. temperatureto reflux for 2 h
5. filtrationthe mixture was filtered through a pad of Celite
6. customThe filtrate was separated
7. extractionthe aqueous layer was extracted with EtOAc (2×20 mL)
8. washThe organics were washed with water (25 mL) and brine (25 mL)
9. dry with materialdried (MgSO4)
10. concentrationconcentrated
11. customThe residue was purified by silica gel chromatography (Isco Sg100c, RediSep 12 g cartridge
12. wait10% to 30% EtOAc:hexanes over 15 min