反应详情

In a 125 mL single neck round bottom flask with reflux condenser, 4-hydroxy-(6-phenyl)-thieno[3,2-d]pyrimidine was combined with thiphenylphosphine polymers (900 mg, 2.7 mmole), carbon tetrachloride (1.1 mL, 11 mmole) and dichloroethane (15 mL). Boiling chips were added and the mixture was refluxed for 18 hours. The mixture was cooled to ambient temperature and filtered into a second single neck round bottom flask. The polymer was washed with 25 mL 10% dichloroethane/tert-butanol. The organic layers were combined and 5-amino-indole (212 mg, 1.6 mmole) was added and the resulting solution was refluxed for 18 hours. The reaction mixture was cooled to ambient temperature and concentrated to a green-brownish residue. The residue was partitioned between 1 N NaOH and 15% 2-propanol/chloroform. The aqueous layer is extracted 2 times with 15 mL 15% isopropanol/CHCl3. The organic layers were combined and dried over sodium sulfate and concentrated to a black residue. The residue was triturated with methanol to give 57 mg of product: MP: 255-258° C. (dec); anal. RP18-HPLC RT: 4.38 minutes; TS-MS: 343 (M+1).

1. temperatureIn a 125 mL single neck round bottom flask with reflux condenser
2. additionBoiling chips were added
3. temperaturethe mixture was refluxed for 18 hours
4. filtrationfiltered into a second single neck round bottom flask
5. washThe polymer was washed with 25 mL 10% dichloroethane/tert-butanol
6. temperaturethe resulting solution was refluxed for 18 hours
7. temperatureThe reaction mixture was cooled to ambient temperature
8. concentrationconcentrated to a green-brownish residue
9. customThe residue was partitioned between 1 N NaOH and 15% 2-propanol/chloroform
10. extractionThe aqueous layer is extracted 2 times with 15 mL 15% isopropanol/CHCl3
11. dry with materialdried over sodium sulfate
12. concentrationconcentrated to a black residue
13. customThe residue was triturated with methanol