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HRID2299949

反应详情

EQUATION

反应方程式

HRID 2299949 的结构方程式

REACTANTS

反应物

3
结构：[Br-].[K+]
HCID253877

Potassium bromide

BrK

结构：NC(=O)c1ccc(-c2ccc(-c3ccn([C@H](CC(=O)OCc4ccccc4)C(=O)N[C@H](CO)Cc4ccccc4)c3)cc2)cc1
HCID15459676

未命名化合物

结构：NC(=O)c1ccc(-c2ccc(-c3ccn([C@H](CC(=O)O)C(=O)N[C@H](CO)Cc4ccccc4)c3)cc2)cc1
HCID53819558

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)c1ccc(-c2ccc(-c3ccn([C@H](CC(=O)O)C(=O)NC(CO)Cc4ccccc4)c3)cc2)cc1
HCID53819559

未命名化合物

收率 95%

PROCEDURE

实验过程

According to the procedure described in Example 1(a), N-(1(S)-benzyl-2-hydroxyethyl)-3(R)-[3-(4′-carbamoylbiphenyl-4-yl)-1H-pyrrol-1-yl]succinamic acid benzyl ester was hydrogenolyzed to N-(1(S)-benzyl-2-hydroxyethyl)-3(R)-[3-(4′-carbamoylbiphenyl-4-yl)-1H-pyrrol-1-yl]succinamic acid in 95% yield, mp 218-20° C. 1H NMR (DMSO-d6): ∂ 8.12 (d, 1H, J=8.5 Hz), 7.97 (s, 1H), 7.88 (d, 2H, J=8.5 Hz), 7.72 (d, 2H, J=8.5 Hz), 7.57 (d, 2H, J=8.1 Hz), 7.33 (bs, 1H), 7.24 (s, 1H), 7.22-7.11 (m, 6H), 6.80 (bs, 1H), 6.42 (bs, 1H), 4.98-4.90 (bm, 1H), 4.80-4.72 (m, 1H), 3.82-3.76 (m, 1H), 2.82-2.70 (m, 2H), 2.62-2.50 (m, 1H). IR (KBr): 3402, 2925, 1658, 1601, 1400, 1202, 825, 782, 702, 633 cm−1. HRFABMS: Calculated for C30H29N3O5Cs (M+Cs+): 644.1162. Found: 644.1147. Anal. Calculated for C30H29N3O5.0.3CHCl3: C, 66.49; H, 5.40; N, 7.68. Found: C, 66.30; H, 5.50; N, 7.50.