HRID2300518

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7369

Benzenesulfonyl chloride

C6H5ClO2S

反应SMILES：CC(C)(C)OC(=O)COc1cccc(CNCc2ccc(-n3ccnc3)cc2)c1

HCID54411937

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3ccnc3)cc2)S(=O)(=O)c2ccccc2)c1

HCID54467696

未命名化合物

PROCEDURE

实验过程

The title compound of Step B was prepared from {3-[(4-imidazol-1-yl-benzylamino)-methyl]phenoxy}-acetic acid tert-butyl ester of Step A and benzenesulfonyl chloride following the method described in Example 3, Step B. 1H NMR (400 MHz, CDCl3) δ 7.86 (m, 3H), 7.62-7.52 (m, 3H), 7.22 (m, 6H), 7.15 (t, 1H), 6.71 (d, 1H), 6.61 (d, 1H), 6.56 (s, 1); MS 534 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-065268947b2949d3a6f1ae0d7914d127
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06498172B1
来源说明: uspto-grants-2002_12

反应SMILES

[C:1]([O:5][C:6](=[O:29])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH:28]=[CH:27][N:26]=[CH:25]3)=[CH:20][CH:19]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:30]1([S:36](Cl)(=[O:38])=[O:37])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[C:1]([O:5][C:6](=[O:29])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]([S:36]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)(=[O:38])=[O:37])[CH2:17][C:18]2[CH:19]=[CH:20][C:21]([N:24]3[CH:28]=[CH:27][N:26]=[CH:25]3)=[CH:22][CH:23]=2)[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]