Benzoylacetone → (2S)-2-{[(Z)-1-methyl-3-oxo-3-phenyl-1-propenyl]amino}-3-[4-(2-{5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}ethoxy)phenyl]propanoic acid

HRID 2300625Notes

Reaction equation

HRID 2300625 reaction equation
[NH2:1][C@@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)[O:19][C:20]=2[CH3:21])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].[C:32]([CH2:40][C:41](=O)[CH3:42])(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH3:42]/[C:41](/[NH:1][C@@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]3[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=3)[O:19][C:20]=2[CH3:21])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4])=[CH:40]/[C:32](=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 7166BenzoylacetoneHCID 18343039(2S)-2-amino-3-[4-(2-{5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3oxazol-4-yl}ethoxy)phenyl]propanoic acid

Product 1

HCID 69836658(2S)-2-{[(Z)-1-methyl-3-oxo-3-phenyl-1-propenyl]amino}-3-[4-(2-{5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}ethoxy)phenyl]propanoic acid

Procedure

The title compound was prepared (as described above for the preparation of Example 2) from 40 mg (0.092 mmol) of Intermediate 50 and 15 mg (0.092 mmol) of benzoylacetone to yield 32 mg of Example 7: TLC (DCM/MeOH, 4/1): Rf=0.48; 1H NMR (DMSO-d6, 300 MHz) δ11.49 (d, 1H, J=9.8), 8.17 (d, 2h, J=8.9), 7.9 (d, 2H, J=8.9), 7.85 (m, 2H), 7.44 (m, 3H), 7.19 (d, 2H, J=8.8), 6.89 (d, 2H, J=8.8), 5.60 (s, 1H), 4.23 (t, 2H, J=6.0), 4.16 (m, 1H), 3.21 (m, 2H), 2.99 (t, 2H, J=6.0), 2.82 (dd, 1H, J=14.2, 9.8), 2.42 (s, 3H), 1.78 (s, 3H); low resolution MS (ES+)m/e 579.0 (MH+).

Sources & evidence

ORD record
ord-ff1508f7520748c881836fda781b9cab
Source dataset
uspto-grants-2002_12
Patent number
US06498174B1

Reaction notes

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