反应详情

温度

80 °C

(R)-1-[6-(2,4-Difluoro-phenoxy)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino]-propan-2-ol (258 mg) was dissolved in 8 mL MeOH, and 0.6 mL of 6M HCl was added. The reaction mixture was heated to 80° C. for 3.5 hours, then cooled. The reaction mixture was quenched by addition to water, and was partitioned between water and ethyl acetate. The organic layer was separated, dried over MgSO4, filtered, and evaporated under reduced pressure. The residue was purified by flash chromatography (10% MeOH in methylene chloride) to give 116 mg of (R)-1-[6-(2,4-Difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino]-propan-2-ol. Mass Spec. M+H=322.

1. temperaturecooled
2. customThe reaction mixture was quenched by addition to water
3. customwas partitioned between water and ethyl acetate
4. customThe organic layer was separated
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated under reduced pressure
8. customThe residue was purified by flash chromatography (10% MeOH in methylene chloride)