反应详情

4-{5-Acetyl-6-methyl-2-thioxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-4-pyrimidinyl}benzonitrile (Example 1; 100 mg, 0.24 mmol) is dissolved in 3 ml THF. After addition of pyridine (21 mg, 0.26 mmol) and propanoyl chloride (22 mg, 0.24 mmol), the reaction mixture is stirred at room temperature overnight and is then quenched with 10 ml water. After extraction with ethyl acetate (2×10 ml), the organic layer is dried with sodium sulfate, and the crude product is purified via flash chromatography on silica gel using a gradient of cyclohexane/ethyl acetate.

1. customis then quenched with 10 ml water
2. extractionAfter extraction with ethyl acetate (2×10 ml)
3. dry with materialthe organic layer is dried with sodium sulfate
4. customthe crude product is purified via flash chromatography on silica gel using a gradient of cyclohexane/ethyl acetate