HRID2303362

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O

HCID6364642

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine

C18H17NO4

结构：COc1cc(-c2cc(CNCCO[Si](C)(C)C(C)(C)C)ccn2)cc(OC)c1OC

HCID18460594

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2cc(CN(CCO[Si](C)(C)C(C)(C)C)C(=O)[C@H](C)NC(=O)OCC3c4ccccc4-c4ccccc43)ccn2)cc(OC)c1OC

HCID86758402

未命名化合物

PROCEDURE

实验过程

N-[2-(tert-Butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amine (756 mg) and N-(9-fluorenylmethoxycarbonyl)-L-alanine (544 mg) were treated in the same manner as in Preparation Example 9 to obtain the title compound. Since this compound was unable to be isolated from impurities, it was used in the next reaction without purifying it as it is.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e66b1104d77c49c6b953eb064b635d3f
来源数据集: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06432957B1
来源说明: uspto-grants-2002_08

反应 SMILES

[Si:1]([O:8][CH2:9][CH2:10][NH:11][CH2:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([C:19]2[CH:24]=[C:23]([O:25][CH3:26])[C:22]([O:27][CH3:28])=[C:21]([O:29][CH3:30])[CH:20]=2)[CH:14]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH:31]1[C:43]2[CH:42]([CH2:44][O:45][C:46]([NH:48][C@H:49]([C:51](O)=[O:52])[CH3:50])=[O:47])[C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[C:35]=2[CH:34]=[CH:33][CH:32]=1>>[Si:1]([O:8][CH2:9][CH2:10][N:11]([CH2:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([C:19]2[CH:20]=[C:21]([O:29][CH3:30])[C:22]([O:27][CH3:28])=[C:23]([O:25][CH3:26])[CH:24]=2)[CH:14]=1)[C:51](=[O:52])[C@H:49]([CH3:50])[NH:48][C:46]([O:45][CH2:44][CH:42]1[C:41]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[C:35]2[C:43]1=[CH:31][CH:32]=[CH:33][CH:34]=2)=[O:47])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:2])[CH3:3]