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HRID230716

反应详情

EQUATION

反应方程式

HRID 230716 的结构方程式

REACTANTS

反应物

2
结构：CCS(=O)(=O)O
HCID11668

Ethanesulfonic acid

C2H6O3S

结构：CCS(=O)(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2CC1CCC(F)(F)CC1
HCID11675994

N-[1-[(4,4-Difluorocyclohexyl)methyl]-2-(1,1-dimethylethyl)-1H-benzimidazol-5-yl]ethanesulfonamide

C20H29F2N3O2S

PRODUCTS

生成物

1
结构：CCS(=O)(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2CC1CCC(F)(F)CC1.CCS(=O)(=O)O
HCID16742587

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)OC(C)C
溶剂HCID7915

Isopropyl acetate

C5H10O2

PROCEDURE

实验过程

N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide (101 mg) was dissolved in iso-propylacetate (1.5 ml) at 42° C. and ethane sulphonic acid (20 μl, 95%) was added. Crystallisation started immediately. The slurry was left for three days before it was filtered off and washed with iso-propylacetate (3×200 μl). The product was dried at 40° C. under vacuum to yield 61 mg crystalline N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide esylate salt.

WORKUP

后处理

  1. customCrystallisation
  2. filtrationwas filtered off
  3. washwashed with iso-propylacetate (3×200 μl)
  4. customThe product was dried at 40° C. under vacuum