反应详情

Methyl 4-(3-methyl-pyrazol-1-yl)-2-trifluoromethyl-benzoate (1.19 g) from Example 93, step b) was dissolved in methanol (10 ml) and a solution of 2.5 N sodium hydroxide (3.3 ml) was added. The reaction was heated at reflux for 90 minutes, cooled to room temperature and concentrated in vacuo to dryness. The residue was partitioned between ethyl acetate and 1 N hydrochloric acid. The combined organic extracts were dried over anhydrous sodium sulfate and concentrated in vacuo to give 1.14 g of the title compound as a colorless solid. MS (FAB) m/z: 271 (M+H)+.

1. temperatureThe reaction was heated
2. temperatureat reflux for 90 minutes
3. concentrationconcentrated in vacuo to dryness
4. customThe residue was partitioned between ethyl acetate and 1 N hydrochloric acid
5. dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
6. concentrationconcentrated in vacuo