Hydrochloric Acid → (S)-1-[3-(2-methyl-morpholin-4-yl)-phenyl]-ethylamine Hydrochloric acid Salt

HRID 2307446Notes

Reaction equation

HRID 2307446 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N:16]2[CH2:21][CH2:20][O:19][CH:18]([CH3:22])[CH2:17]2)[CH:11]=1)[CH3:9])(C)(C)C.[ClH:24]>CO>[ClH:24].[CH3:22][CH:18]1[O:19][CH2:20][CH2:21][N:16]([C:12]2[CH:11]=[C:10]([C@@H:8]([NH2:7])[CH3:9])[CH:15]=[CH:14][CH:13]=2)[CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69870688(S)-{1-[3-(2-methyl-morpholin-4-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester

Product 1

HCID 69851400(S)-1-[3-(2-methyl-morpholin-4-yl)-phenyl]-ethylamine Hydrochloric acid Salt

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The solution of (S)-{1-[3-(2-methyl-morpholin-4-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester (2.62 g, 8.19 mmol), and hydrochloric acid (1.0M solution in diethyl ether) (12.3 ml, 3eq) in methanol (25 ml) was stirred at room temperature overnight. Concentrated under vacuum and 2.43 g of hydrochloric acid salt of (S)-1-[3-(2-methyl-morpholin-4-yl)-phenyl]-ethylamine was obtained as yellow solid (quantitative yield).

Workup

  1. concentrationConcentrated under vacuum and 2.43 g of hydrochloric acid salt of (S)-1-[3-(2-methyl-morpholin-4-yl)-phenyl]-ethylamine

Sources & evidence

ORD record
ord-93fb006209e74db9b886aa80df65bdac
Source dataset
uspto-grants-2004_12
Patent number
US06831080B2

Reaction notes

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