Tetrabutylammonium Fluoride → HCID 17934633, compound

HRID 2307591Notes

Reaction equation

HRID 2307591 reaction equation
[Si]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:34]=[CH:35][C:36]=1[CH2:37][O:38][Si](C(C)(C)C)(C)C)[CH2:13][O:14][C:15]1[CH:16]=[C:17]([C:21]2[CH:26]=[CH:25][C:24]([CH:27]([OH:32])[C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:23][C:22]=2[CH3:33])[CH:18]=[CH:19][CH:20]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[OH:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:34]=[CH:35][C:36]=1[CH2:37][OH:38])[CH2:13][O:14][C:15]1[CH:16]=[C:17]([C:21]2[CH:26]=[CH:25][C:24]([CH:27]([OH:32])[C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:23][C:22]=2[CH3:33])[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 22606921HCID 22606921, compound

Product 1

HCID 17934633HCID 17934633, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 g (3 mmol) of 1-{3′-(3,4-bis-(tert-butyldimethylsilanyloxymethyl)benzyloxy]-2-methylbiphenyl-4-yl}-2,2-dimethyl-1-propanol are dissolved in 20 mL of THF and 7.7 mL (7.7 mmol) of 1 M tetrabutylammonium fluoride are added dropwise. After stirring for 1 hour at room temperature followed by the usual treatment, the residue obtained is purified by chromatography on silica gel. The desired product is obtained in the form of a colourless oil (m=1.15 g; Y=90%).

Workup

  1. customthe residue obtained
  2. customis purified by chromatography on silica gel

Sources & evidence

ORD record
ord-49f2e59920c1490abff3427557142cd6
Source dataset
uspto-grants-2004_12
Patent number
US06831106B1

Reaction notes

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