反应详情

N-Methylethanolamine (2.96 g, 39.4 mmol) was added to a solution of methyl 2-chlorosulfonyl-6-nitrobenzoate (5.5 g, 19.7 mmol, prepared according to Example 1 of Part a, supra) in THF (150 ml) and the mixture stirred at 20-25° for 18 hours. After removing THF under reduced pressure, the residue was partitioned between EtOAc and H2O. The organic extract was washed with saturated NaCl solution and dried (Na2SO4). Flash chromatography of the residue over silica gel and eluation with 1% MeOH-99% CHCl3 afforded pure sulfonamide. Recrystallization from EtOAc-hexane gave analytically pure product (5.2 g, 82.9%), m.p. 98-101°.

1. customprepared
2. customAfter removing THF under reduced pressure
3. customthe residue was partitioned between EtOAc and H2O
4. extractionThe organic extract
5. washwas washed with saturated NaCl solution
6. dry with materialdried (Na2SO4)
7. customRecrystallization from EtOAc-hexane