反应详情

A solution of 3.42 g (0.01 mol) of α-acetyl-N-(2-methoxyethyl)-N-methyl-3-nitrostyrenesulfonamide and 1.87 g (0.01 mol) of 3-aminocrotonic acid 2-propoxyethyl ester in 15 ml of isopropanol is heated to reflux for 2 hours, thereupon treated with 1.0 g of Amberlyst® 15 as the catalyst and then heated to reflux for an additional 30 minutes. After concentration under reduced pressure the oily residue is dissolved in methylene chloride, the catalyst remaining behind is removed by filtration under suction, and the filtrate is washed with a saturated aqueous sodium chloride solution, dried over sodium sulfate and concentrated to dryness. The residual oil is chromatographed on 300 g of silica gel with methylene chloride/ethyl acetate (4:1) as the elution agent. The uniform fractions yield an oil which crystallizes upon trituration and leaving to stand under hexane. After recrystallization from ether, there are obtained 2.4 g (47%) of 1,4-dihydro-2,6-dimethyl-5-[(2-methoxyethyl)methylsulfamoyl]-4-(3-nitrophenyl)nicotinic acid 2-propoxyethyl ester, m.p. 67°-70°, as an almost colorless crystalline powder.

1. temperatureto reflux for 2 hours
2. additiontreated with 1.0 g of Amberlyst® 15 as the catalyst
3. temperatureheated
4. temperatureto reflux for an additional 30 minutes
5. concentrationAfter concentration under reduced pressure the oily residue
6. dissolutionis dissolved in methylene chloride
7. customthe catalyst remaining behind is removed by filtration under suction
8. washthe filtrate is washed with a saturated aqueous sodium chloride solution
9. dry with materialdried over sodium sulfate
10. concentrationconcentrated to dryness
11. customThe residual oil is chromatographed on 300 g of silica gel with methylene chloride/ethyl acetate (4:1) as the elution agent
12. customThe uniform fractions yield an oil which
13. customcrystallizes upon trituration
14. customleaving
15. customAfter recrystallization from ether, there