反应详情

Using 2,4-dimethylbenzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from EXAMPLE 56, Part B was converted into the title compound of EXAMPLE 135. 1H NMR (CDCl3) δ: 9.55 (broad s, 1H), 9.35 (broad s, 1H), 7.18 (d, 1H, J=7.7 Hz), 7.01-6.95 (m, 2H), 6.64 (s, 1H), 6.51 (s, 1H), 4.57 (ABq, 2H), 4.254.20 (m, 1H), 4.20 (s, 2H), 3.67 (app t, 1H), 3.50-3.10 (m, 6H), 2.70-2.50 (m, 2H), 2.30 (s, 3H), 2.27 (s, 3H), 2.23-2.10 (m, 2H).