反应详情

A mixture of 0.11 g of 5-(4-fluorophenyl)-4-[4(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-oxo-pyridine (step 5 of Example 1), 3,3 g of bromoethane, 0.2 g of potassium carbonate, and 5 mL of dimethyl formamide (DMF) was stirred for 20 hours and concentrated in vacuo. The residue was triturated with water and extracted with methylene chloride. The methylene chloride extract was dried over MgSO4 and filtered through silica gel. The filtrate was reconcentrated in vacuo and the residue was crystallized from methylene chloride/hexane to give 31 mg of solid: mp 168.5°-170.5° C.

1. concentrationconcentrated in vacuo
2. customThe residue was triturated with water
3. extractionextracted with methylene chloride
4. extractionThe methylene chloride extract
5. dry with materialwas dried over MgSO4
6. filtrationfiltered through silica gel
7. customthe residue was crystallized from methylene chloride/hexane