反应详情

A mixture of 0.11 g of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-oxo-pyridine (step 5 of Example 1), 2.5 g of propargyl bromide, 0.3 g of potassium carbonate, and 5 mL of DMF was stirred for 60 hours and concentrated in vacuo. The residue was triturated with water and extracted with methylene chloride. The methylene chloride extract was dried over MgSO4 and filtered through silica gel. The filtrate was reconcentrated in vacuo and the residue was crystallized from ether/hexane to give 56 mg of white solid: mp 138°-139° C.

1. concentrationconcentrated in vacuo
2. customThe residue was triturated with water
3. extractionextracted with methylene chloride
4. extractionThe methylene chloride extract
5. dry with materialwas dried over MgSO4
6. filtrationfiltered through silica gel
7. customthe residue was crystallized from ether/hexane