反应详情

A suspension of commercially available 4-benzyl-piperidin-4-ol (383 mg, 2.0 mmol). NaHCO3 (672 mg, 8.0 mmol) and 1-(2-chloro-ethyl)-3-(2,6-dimethyl-pyridin-4-yl)-urea (Example D1., 227.7 mg 1.0 mmol) in THF (4 mL) is stirred at 50° C. for 4 days. The mixture is quenched with Na2CO3 (10 mL) and extracted with CH2Cl2 (3×10 mL). The organic extracts are washed with sat. aq. Na2CO3 (10 mL), dried (Na2SO4), filtered and evaporated. The residue is purified by HPLC to provide the title compound.

1. customThe mixture is quenched with Na2CO3 (10 mL)
2. extractionextracted with CH2Cl2 (3×10 mL)
3. washThe organic extracts are washed with sat. aq. Na2CO3 (10 mL)
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. customevaporated
7. customThe residue is purified by HPLC