反应详情

温度

20 °C

The procedure is similar to that described in Example 1, but starting with cyclobutanecarboxylic acid (5 g), N,N'-carbonyldiimidazole (10.5 g) and 2-amino-7chloro-1,8-naphthyridine (7 g). The product produced by filtration (9 g; m.p. 192° C.) is dissolved in boiling acetonitrile (150 cc). After 3 hours' cooling at 20° C., the crystallised solid is separated by filtration, washed with ethyl ether (3×25 cc) and dried at 35° C. under reduced pressure (0.066 kPa). N-(7-Chloro-1,8-naphthyridin-2-yl)cyclobutanecarboxamide (6.3 g) is produced, m.p. 192°-194° C. EXAMPLE 6

1. customThe product produced by filtration (9 g; m.p. 192° C.)
2. dissolutionis dissolved
3. customthe crystallised solid is separated by filtration
4. washwashed with ethyl ether (3×25 cc)
5. customdried at 35° C. under reduced pressure (0.066 kPa)