反应详情

温度

4 °C

The prccedure is similar to that described in Example 1, but starting with nicotinic acid (7.4 g), N,N'-carbonyldiimidazole (9.7 g) and 2-amino-7-methoxy-1,8-naphthyridine (7 g). After filtration, washing with water and drying, the crystallised solid formed during the reaction (10.3 g; m.p. 245° C.) is dissolved in boiling 1-propanol (900 cc). After being cooled for 3 hours at 4° C., the crystallised solid is separated by filtration, washed with 1-propanol (3×20 cc) and dried at 50° C. under reduced pressure (0.067 kPa). N-(7-methoxy-1,8-naphthyridin-2-yl)-3-pyridylcarboxamide (8.7 g) is produced, m.p. 247° C.

1. filtrationAfter filtration
2. washwashing with water
3. customdrying
4. customthe crystallised solid formed during the reaction (10.3 g; m.p. 245° C.)
5. dissolutionis dissolved
6. customthe crystallised solid is separated by filtration
7. washwashed with 1-propanol (3×20 cc)
8. customdried at 50° C. under reduced pressure (0.067 kPa)