反应详情

The product from Example 12d (60 mg, 0.271 mmol) was reacted with the product from Example 50b (66 mg, 0.271 mmol) for 25 h giving following the procedure from Example 1g the crude title compound that was triturated with 3:1 ether/THF providing the title compound as a hydrochloride salt (121 mg, 96%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 0.97 (d, J=6.62 Hz, 6H) 2.24 (m, J=6.62 Hz, 1 H) 2.34 (s, 3 H) 2.89 (d, J=7.35 Hz, 2 H) 3.72 (s, 3 H) 6.27 (d, J=6.99 Hz, 1 H) 6.84 (d, J=8.46 Hz, 2 H) 7.10 (d, J=8.09 Hz, 1 H) 7.23-7.32 (m, 4 H) 7.81 (d, J=8.46 Hz, 1 H) 8.41 (d, J=6.99 Hz, 1 H) 9.07 (d, J=8.46 Hz, 1 H) 11.09 (br s, 1 H) 14.40 (br s, 1 H); MS (ESI+) m/z 430 (M−Cl)+; (ESI−) m/z 428 (M−HCl)−.

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