反应详情

The title compound was prepared using General Experimental Procedure A (Suzuki coupling reaction) from 2-bromobenzo[4,5]imidazo[1,2-a]pyrimidine and (4-cyano-3-fluorophenyl)boronic acid on a 0.1 mmol scale. The residue was washed with water (3×5 mL), EtOAc (3×2 mL), and DCM (3×2 mL) and dried under high vacuum to afford 4-(Benzo[4,5]imidazo[1,2-a]pyrimidin-2-yl)-2-fluorobenzonitrile (T747) as a orange solid (12 mg, 41%). 1H NMR (400 MHz, DMSO-d6): δ 9.67 (d, J=7.2 Hz, 1H), 8.86 (dd, J=5.6, 2.0 Hz, 1H), 8.74 (m, 1H), 8.33 (d, J=7.6 Hz, 1H), 7.91 (d, J=7.2 Hz, 1H), 7.84 (d, J=9.2 Hz, 1H), 7.760 (t, J=8.8 Hz, 1H), 7.54 (t, J=7.2 Hz, 1H), 7.42 (t, J=7.6 Hz, 1H); MS (ESI) m/z [M+H]+289.

1. washThe residue was washed with water (3×5 mL), EtOAc (3×2 mL), and DCM (3×2 mL)
2. customdried under high vacuum