反应详情

Allyl (rac)-4-[4-cyano-2-(methylsulfanyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate (750 mg, 1.54 mmol) was dissolved in THF (10 ml), and morpholine (201 mg, 2.308 mmol) was added. The reaction solution was saturated with argon (argon was passed through the solution for 30 min). Tetrakis(triphenylphosphine)palladium(0) (7.47 mg, 0.006 mmol) was then added, and the mixture was stirred at RT overnight. Since HPLC showed little conversion, more tetrakis(triphenylphosphine)palladium(0) (7.47 mg, 0.006 mmol) was added and the mixture was stirred at RT for a further 3 h. The content of the flask was then filtered through kieselguhr and the residue was washed with THF. The filtrate was concentrated under reduced pressure and the residue was recrystallized from diethyl ether (15 ml). The crystals were filtered off with suction and dried under high vacuum. This gave 663 mg (96% of theory) of the target compound.

1. additionwas added
2. stirringthe mixture was stirred at RT for a further 3 h
3. filtrationThe content of the flask was then filtered through kieselguhr
4. washthe residue was washed with THF
5. concentrationThe filtrate was concentrated under reduced pressure
6. customthe residue was recrystallized from diethyl ether (15 ml)
7. filtrationThe crystals were filtered off with suction
8. customdried under high vacuum