HRID2361991

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)Oc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1

HCID10895791

Fmoc-L-Tyr(tBu)-OH

C28H29NO5

HCID86652569

未命名化合物

PRODUCTS

生成物

结构：CCOC(OCC)[C@H](C)N(Cc1csc2ccc(Cl)nc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21

HCID86698529

未命名化合物

PROCEDURE

实验过程

According to the procedure described in the synthesis method of Compound III-5, (S)—N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine (Compound IX-11) (996 mg, 3.03 mmol) was coupled with (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoic acid (1.53 g, 3.33 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=98:2) to obtain the title compound (1.29% g, 55%).

WORKUP

后处理

customthe obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=98:2)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fa5ae46ed9a844b388b7b82aaf0ace1d
来源数据集: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08691819B2
来源说明: uspto-grants-2014_04

反应 SMILES

[Cl:1][C:2]1[N:7]=[C:6]2[C:8]([CH2:11][NH:12][C@@H:13]([CH3:21])[CH:14]([O:18][CH2:19][CH3:20])[O:15][CH2:16][CH3:17])=[CH:9][S:10][C:5]2=[CH:4][CH:3]=1.[CH:22]1[C:34]2[CH:33]([CH2:35][O:36][C:37]([NH:39][C@@H:40]([CH2:44][C:45]3[CH:50]=[CH:49][C:48]([O:51][C:52]([CH3:55])([CH3:54])[CH3:53])=[CH:47][CH:46]=3)[C:41](O)=[O:42])=[O:38])[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:26]=2[CH:25]=[CH:24][CH:23]=1>>[C:52]([O:51][C:48]1[CH:47]=[CH:46][C:45]([CH2:44][C@H:40]([NH:39][C:37](=[O:38])[O:36][CH2:35][CH:33]2[C:34]3[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=3[C:27]3[C:32]2=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:41]([N:12]([CH2:11][C:8]2[C:6]3=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=[C:5]3[S:10][CH:9]=2)[C@@H:13]([CH3:21])[CH:14]([O:18][CH2:19][CH3:20])[O:15][CH2:16][CH3:17])=[O:42])=[CH:50][CH:49]=1)([CH3:55])([CH3:53])[CH3:54]