反应详情

With 5 ml of ethanol were mixed 1 g of N-cyano-N'-{2-[(5-methyl-4-imidazolyl)methylthio]ethyl}-S-methylisothiourea and 2.6 g of DL-β-hydroxyphenethylamine, and the resulting mixture was subjected to reaction under reflux for 5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the oily substance thus obtained was washed with 20 ml of diethyl ether and then purified by a column chromatography (Wako Silica Gel C-200, eluent; chloroform:methanol=10:1 by volume) to obtain 0.27 g (yield 20%) of amorphous N-cyano-N'-(β-hydroxyphenethyl)-N"-{2-[(5-methyl-4-imidazolyl)methylthio]ethyl}guanidine.

1. customthe resulting mixture was subjected to reaction
2. temperatureunder reflux for 5 hours
3. customAfter completion of the reaction
4. customthe solvent was removed by distillation under reduced pressure
5. customthe oily substance thus obtained
6. washwas washed with 20 ml of diethyl ether
7. custompurified by a column chromatography (Wako Silica Gel C-200, eluent; chloroform:methanol=10:1 by volume)