反应详情

In a 5 ml glass tube were placed 2-chloro-oxazole-4-carboxylic acid [1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-amide (40 mg, 0.10 mmol), K2CO3(17 mg, 0.12 mmol), 3-tert-butyl phenol (18 mg, 0.12 mmol), DMF (1 mL), and a magnetic stir bar. The vial was sealed with septum and placed into the Microwave cavity. The vial was irradiated in a Microwave synthesizer at 130° C. for 10 min. The reaction mixture was diluted with EtOAc, and washed with saturated ammonium chloride and water. The organic layer was dried over anhydrous MgSO4 and concentrated under reduced pressure. The crude residue was purified by column chromatography (gradient 12% to 100% EtOAc in n-hexane) to give title compound (90 mg, 80%).

1. customIn a 5 ml glass tube were placed
2. customThe vial was sealed with septum
3. customThe vial was irradiated in a Microwave synthesizer at 130° C. for 10 min
4. washwashed with saturated ammonium chloride and water
5. dry with materialThe organic layer was dried over anhydrous MgSO4
6. concentrationconcentrated under reduced pressure
7. customThe crude residue was purified by column chromatography (gradient 12% to 100% EtOAc in n-hexane)