反应详情

The title compound was prepared by substituting (2S,3aS,7aS)-1-(tert-butoxycarbonyl)octahydro-1H-indole-2-carboxylic acid for (S)-2-(tert-butoxycarbonyl(methyl)amino)-4,4-dimethylpentanoic acid and (3aR,4S,6aS)-2-(5-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine from Example 262 Step B for (3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-amine in the procedure described in Example 587: 1H NMR (500 MHz, pyridine-d5) δ ppm 8.66-8.59 (m, 1H), 8.32 (d, J=7.9, 1H), 7.67 (dd, J=8.9, 2.5, 1H), 6.36 (d, J=8.9, 1H), 4.38-4.29 (m, 1H), 3.94 (dd, J=10.6, 4.7, 1H), 3.72 (d, J=8.1, 1H), 3.58 (t, J=9.5, 2H), 3.33 (d, J=6.7, 1H), 3.23 (dd, J=9.4, 4.7, 1H), 3.18-2.94 (m, 1H), 2.80-2.68 (m, 1H), 2.66-2.57 (m, 1H), 2.27 (ddd, J=12.8, 10.6, 7.0, 1H), 2.15-2.05 (m, 1H), 1.96 (dddd, J=18.4, 16.6, 8.6, 4.9, 2H), 1.88-1.79 (m, 1H), 1.70-1.35 (m, 8H), 1.35-1.27 (m, 1H), 1.16 (tt, J=15.5, 6.5, 1H); MS (ESI+) m/z 423 (M+H)+.