反应详情

温度

100 °C

5-[(4-fluorophenyl)methyl]-3-{[4-(methyloxy)phenyl]amino}-2-pyridinecarbonitrile (505 mg, 1.52 mmol) was dissolved in ethanol (50 mL) and 50% sodium hydroxide was added and the mixture was heated at 100° C. for 1 hour. The reaction was cooled to ambient temperature, concentrated under reduced pressure, and acidified with 6 N hydrochloric acid. The aqueous layer was extracted with ethyl acetate and the organics were dried over sodium sulfate and concentrated under reduced pressure to yield 5-[(4-fluorophenyl)methyl]-3-{[4-(methyloxy)phenyl]amino}-2-pyridinecarboxylic acid (560 mg, 95% yield). 1H NMR (CDCl3/methanol-d4) δ 7.95 (s, 1 H), 7.32 (s, 1 H), 7.01-6.98 (m, 4 H), 6.93-6.83 (m, 4 H), 3.86 (s, 2 H), 3.75 (s, 3 H); MS m/z 353 (M+1).

1. temperatureThe reaction was cooled to ambient temperature
2. concentrationconcentrated under reduced pressure
3. extractionThe aqueous layer was extracted with ethyl acetate
4. dry with materialthe organics were dried over sodium sulfate
5. concentrationconcentrated under reduced pressure